RAF Typhoon fighter aircraft have operated alongside French warplanes in a combined operation against an hidden munitions depot in Syrian territory employed by the IS group, according to the UK's MoD.
The site, located using surveillance, was believed to be housing weapons and explosive materials, the announcement noted, and was located in mountainous terrain just above the historic site of Palmyra in central Syria.
"Our aircraft used Paveway IV guided bombs to target a series of entry passages providing entry to the depot... initial indications suggest the target was engaged successfully," officials stated.
There was no evidence of any civilian casualties in the operation late on Saturday and every plane involved made a safe return, the MoD added.
The Typhoon fighters were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as the so-called Islamic State - established militant control over significant areas in Syria and Iraq before its territorial defeat in 2019.
"This strike underscores British leadership, and resolve to work closely with allied nations, to stamp out any resurgence of Daesh and their dangerous and violent ideologies in the Middle East," the British Defence Secretary John Healey said.
UK warplanes have performed patrols over Syria to "forestall any efforts to regroup" of Islamic State subsequent to its military defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I extend gratitude to the personnel of our armed forces participating in this operation for their expertise and their valour," he commented. "Including them were numerous UK service members on duty over Christmas and New Year. This action, to take out terrorist threats who pose a risk to our safety, highlights how our armed forces are always on standby, continuously, protecting the UK within its borders and strong abroad."
Last December, the American forces executed what it called a "major assault" on IS targets in Syria, after an assault claimed the lives of two American soldiers and a civilian interpreter in Palmyra.
The United Nations reports IS still maintains an estimated 5,000 to 7,000 combatants in Syria and Iraq.